Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | S100A4 | P26447 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SGK1 | O00141 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448863 | 0.86 | MAPT (0.71) | MAPTSMN1; SMN2MAOBS100A4HSD17B1 | |
| SCHEMBL12332689 | 0.84 | MAPT (0.68) | MAPTSMN1; SMN2MAOBS100A4HSD17B1 | |
| SCHEMBL12101146 | 0.82 | TSHR (0.50) | MAPTRAB9ANPC1 | |
| SCHEMBL10296041 | 0.82 | MAPT (0.79) | MAPTSMN1; SMN2MAOBS100A4HSD17B1 | |
| SCHEMBL3282326 | 0.81 | MEN1 (0.55) | MAPTSMN1; SMN2HPGDLMNAALDH1A1 | |
| SCHEMBL10178616 | 0.81 | NPSR1 (0.38) | MAPTSMN1; SMN2ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL13232064 | 0.80 | MAPT (0.63) | MAPTSMN1; SMN2MAOBS100A4HSD17B1 | |
| Hydrogen Sulfide SCHEMBL28788713 | 0.80 | MAPT (0.76) | MAPTSMN1; SMN2MAOBS100A4HSD17B1 | |
| SCHEMBL2772796 | 0.78 | MAPT (0.61) | MAPTSMN1; SMN2MAOBS100A4HSD17B1 | |
| SCHEMBL10955727 | 0.78 | SMN1; SMN2 (0.61) | MAPTSMN1; SMN2MAOBS100A4HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727982-B2 | N-(5-bromo-2-pyridinyl)-(2-4-[(2-aminosulfonyl)phenyl]phenylcarbonylamino)phenylcarboxamide; potent and highly selective inhibitors; coagulation disorders; antithrombotic agents; diagnostic reagents; good bioavailability and/or solubility | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-7727981-B2 | monoamidino-containing compounds having good bioavailability and/or solubility, used as potent and specific inhibitors of blood coagulation in mammals, and as therapeutic agents for disease states characterized by coagulation disorders | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-7314874-B2 | N-(5-bromo-2-pyridinyl)-(2-4-[(2-aminosulfonyl)phenyl]phenylcarbonylamino)phenylcarboxamide;modified amidine elements of high potency in vitro, excellent pharmacological and pharmaceutical properties in vivo | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-01-01 | — | — | US | disclosed |