Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499798 | 0.88 | CYSLTR1 (0.49) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL8499801 | 0.88 | CYSLTR1 (0.49) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL4416602 | 0.87 | CYSLTR1 (0.43) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL8500846 | 0.87 | CYSLTR1 (0.44) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL8499871 | 0.85 | CYSLTR1 (0.52) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL8500790 | 0.85 | CYSLTR1 (0.52) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL12203099 | 0.85 | CYSLTR1 (0.50) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL2845349 | 0.85 | CYSLTR1 (0.52) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL13068600 | 0.85 | CYSLTR1 (0.52) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL | |
| SCHEMBL13352375 | 0.85 | CYSLTR1 (0.52) | CYSLTR1CYP2C8CYSLTR2MEN1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2181986-A1 | Process for the preparation of a precursor of montelukast | Synthon B.V. (NL) | 2010-05-05 | — | — | EP | disclosed |
| EP-1740545-B1 | PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR | SYNTHON BV (NL) | 2010-03-24 | — | — | EP | disclosed |
| WO-2008049922-A2 | A NEW PROCESS FOR THE PREPARATION OF MONTELUKAST | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2008-05-02 | — | — | WO | disclosed |
| WO-2008009970-A2 | PROCESS FOR THE PREPARATION OF MONTELUKAST | PLIVA HRVATSKA D.O.O. (HR) | 2008-01-24 | — | — | WO | disclosed |
| WO-2007057225-A2 | PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR | SYNTHON B.V. (NL) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007057228-A1 | A NEW INTERMEDIATE FOR MAKING MONTELUKAST AND RELATED COMPOUNDS | SYNTHON B.V. (NL) | 2007-05-24 | — | — | WO | disclosed |