Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279580 | 0.85 | KMT2A (0.62) | KMT2AMEN1L3MBTL1GLAGAA | |
| SCHEMBL277405 | 0.84 | KMT2A (0.61) | KMT2AMEN1L3MBTL1GLAGAA | |
| SCHEMBL11919030 | 0.84 | KMT2A (0.61) | KMT2AMEN1L3MBTL1GLAGAA | |
| SCHEMBL277558 | 0.83 | MEN1 (0.64) | KMT2AMEN1L3MBTL1GLAGAA | |
| SCHEMBL11916012 | 0.81 | KMT2A (0.59) | KMT2AMEN1L3MBTL1GLAGAA | |
| SCHEMBL22515316 | 0.81 | KMT2A (0.59) | KMT2AMEN1L3MBTL1GLAGAA | |
| SCHEMBL3980169 | 0.78 | MEN1 (0.74) | KMT2AMEN1L3MBTL1GLAGAA | |
| SCHEMBL279608 | 0.78 | MEN1 (0.74) | KMT2AMEN1L3MBTL1GLAGAA | |
| SCHEMBL5000477 | 0.78 | AKT3 (0.66) | KMT2AMEN1L3MBTL1MMP12LMNA | |
| SCHEMBL12313823 | 0.77 | MEN1 (0.72) | KMT2AMEN1L3MBTL1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056311-A1 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | disclosed |