Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 3/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 9/20 | 0.46 |
| ▸ | JAK1 | P23458 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | TYK2 | P29597 | 3/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12322696 | 0.91 | IRAK4 (0.52) | IRAK4SYKJAK3JAK1JAK2 | |
| SCHEMBL2344922 | 0.85 | IRAK4 (0.58) | IRAK4JAK3JAK1JAK2TYK2 | |
| SCHEMBL12322689 | 0.85 | IRAK4 (0.58) | IRAK4JAK3JAK1JAK2TYK2 | |
| SCHEMBL2344938 | 0.85 | IRAK4 (0.58) | IRAK4JAK3JAK1JAK2TYK2 | |
| SCHEMBL2344933 | 0.85 | IRAK4 (0.58) | IRAK4JAK3JAK1JAK2TYK2 | |
| SCHEMBL12321401 | 0.84 | IRAK4 (0.57) | IRAK4JAK3JAK1JAK2TYK2 | |
| SCHEMBL12321546 | 0.84 | JAK3 (0.56) | IRAK4CSF1RJAK3JAK1JAK2 | |
| SCHEMBL12322005 | 0.84 | JAK3 (0.56) | IRAK4CSF1RJAK3JAK1JAK2 | |
| SCHEMBL2342512 | 0.84 | JAK3 (0.56) | IRAK4CSF1RJAK3JAK1JAK2 | |
| SCHEMBL2342508 | 0.84 | JAK3 (0.56) | IRAK4CSF1RJAK3JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010058846-A1 | 4,6-DIAMINONICOTINAMIDE COMPOUND | アステラス製薬株式会社 (JP) | 2010-05-27 | — | — | WO | disclosed |