Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 8/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735560 | 0.83 | TNK2 (0.68) | TNK2EGFRALDH1A1HPGDTSHR | |
| SCHEMBL759173 | 0.81 | EGFR (0.52) | TNK2EGFRALDH1A1HPGDTSHR | |
| SCHEMBL1787179 | 0.76 | TNK2 (0.58) | TNK2EGFRALDH1A1HPGDTSHR | |
| SCHEMBL2977130 | 0.76 | TNK2 (0.58) | TNK2EGFRALDH1A1HPGDTSHR | |
| SCHEMBL6848486 | 0.76 | TNK2 (0.58) | TNK2EGFRALDH1A1HPGDTSHR | |
| SCHEMBL2975999 | 0.73 | KDM4E (0.74) | TNK2ALDH1A1HPGDAURKACHEK1 | |
| SCHEMBL1785983 | 0.73 | TNK2 (0.54) | TNK2EGFRALDH1A1HPGDTSHR | |
| SCHEMBL1785974 | 0.73 | KDM4E (0.74) | TNK2ALDH1A1HPGDAURKACHEK1 | |
| SCHEMBL13361104 | 0.72 | TNK2 (0.70) | TNK2EGFRALDH1A1HPGDTSHR | |
| SCHEMBL2975737 | 0.72 | TNK2 (0.47) | TNK2EGFRALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054285-A2 | FUSED BICYCLIC AND TRICYCLIC PYRIMIDINE COMPOUNDS AS TYROSINE KINASE INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-05-14 | — | — | WO | disclosed |