Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 20/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 19/20 | 0.69 |
| ▸ | AURKA | O14965 | 12/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12119305 | 0.92 | PDPK1 (0.80) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL13354870 | 0.90 | PDPK1 (0.86) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL12122694 | 0.82 | PDPK1 (0.58) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL12119515 | 0.82 | PDPK1 (1.00) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL12119122 | 0.82 | PDPK1 (1.00) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL3123947 | 0.81 | PDPK1 (0.79) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL16966452 | 0.81 | PDPK1 (0.79) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL16966462 | 0.81 | PDPK1 (0.79) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL13354779 | 0.80 | PDPK1 (0.69) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL12119301 | 0.79 | PDPK1 (0.54) | PDPK1AURKBAURKAROCK1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |