Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 1.00 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.82 |
| ▸ | RET | P07949 | 4/20 | 0.82 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.82 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.82 |
| ▸ | LCK | P06239 | 3/20 | 0.82 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.82 |
| ▸ | BLK | P51451 | 3/20 | 0.82 |
| ▸ | STK3 | Q13188 | 3/20 | 0.82 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.82 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.82 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.82 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.82 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.82 |
| ▸ | FLT1 | P17948 | 3/20 | 0.82 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.82 |
| ▸ | FLT4 | P35916 | 3/20 | 0.82 |
| ▸ | FLT3 | P36888 | 3/20 | 0.82 |
| ▸ | PIM1 | P11309 | 2/20 | 0.82 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1334236 | 0.91 | KDR (1.00) | KDRROCK2RETAURKBMAP4K4 | |
| SCHEMBL1335520 | 0.90 | KDR (1.00) | KDRROCK2RETAURKBMAP4K4 | |
| SCHEMBL1333801 | 0.90 | KDR (1.00) | KDRROCK2RETAURKBMAP4K4 | |
| SCHEMBL1333837 | 0.89 | KDR (0.79) | KDRROCK2RETAURKBMAP4K4 | |
| SCHEMBL1335430 | 0.89 | KDR (0.79) | KDRROCK2RETAURKBMAP4K4 | |
| SCHEMBL1333150 | 0.88 | KDR (1.00) | KDRROCK2RETAURKBMAP4K4 | |
| SCHEMBL1334194 | 0.87 | KDR (0.81) | KDRROCK2RETAURKBMAP4K4 | |
| SCHEMBL1335271 | 0.87 | KDR (0.82) | KDRROCK2RETAURKBMAP4K4 | |
| SCHEMBL1335607 | 0.87 | KDR (0.82) | KDRROCK2RETAURKBMAP4K4 | |
| SCHEMBL1333324 | 0.87 | KDR (1.00) | KDRROCK2RETAURKBMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060287370-A1 | Isoindolinone kinase inhibitors | CURTIN MICHAEL L | 2006-12-21 | — | — | US | claimed |
| US-7129260-B2 | Isoindolinone kinase inhibitors | ABBOTT LABORATORIES (US) | 2006-10-31 | — | — | US | claimed |
| EP-1633710-A1 | ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS | Abbott Laboratories (US) | 2006-03-15 | — | — | EP | claimed |
| US-20050026976-A1 | Isoindolinone kinase inhibitors | ABBOTT LABORATORIES | 2005-02-03 | — | — | US | claimed |
| WO-2004108672-A1 | ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-16 | — | — | WO | claimed |
| US-20110275630-A1 | ISOINDOLINONE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2011-11-10 | — | — | US | disclosed |
| US-20100076051-A1 | ISOINDOLINONE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2010-03-25 | — | — | US | disclosed |
| US-20060287370-A1 | Isoindolinone kinase inhibitors | CURTIN MICHAEL L | 2006-12-21 | — | — | US | disclosed |
| US-7129260-B2 | Isoindolinone kinase inhibitors | ABBOTT LABORATORIES (US) | 2006-10-31 | — | — | US | disclosed |
| US-20050026976-A1 | Isoindolinone kinase inhibitors | ABBOTT LABORATORIES | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287370-A1 | Isoindolinone kinase inhibitors | ABL1, LCK, MAP3K7 | KDR 527/4885ROCK2 264/4885RET 196/4885 |
| US-20050026976-A1 | Isoindolinone kinase inhibitors | ABL1, LCK, MAP3K7 | KDR 527/4885ROCK2 264/4885RET 196/4885 |
| US-20100076051-A1 | ISOINDOLINONE KINASE INHIBITORS | ABL1, LCK, MAP3K7 | KDR 527/4885ROCK2 264/4885RET 196/4885 |
| US-20110275630-A1 | ISOINDOLINONE KINASE INHIBITORS | MAP3K7, MAP3K5, MAP3K20 | KDR 909/4885ROCK2 316/4885RET 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.