Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 17/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 16/20 | 0.62 |
| ▸ | AURKA | O14965 | 10/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.62 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13354725 | 0.94 | PDPK1 (0.70) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12122764 | 0.93 | PDPK1 (0.71) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL13354774 | 0.92 | PDPK1 (0.59) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12122718 | 0.90 | PDPK1 (0.61) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL1319039 | 0.89 | PDPK1 (0.58) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12122729 | 0.86 | PDPK1 (0.58) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL13354767 | 0.85 | PDPK1 (0.62) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL13354798 | 0.85 | PDPK1 (0.53) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12122780 | 0.84 | PDPK1 (0.71) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL1318388 | 0.83 | PDPK1 (0.65) | PDPK1AURKBAURKAROCK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |