Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 4/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12122786 | 0.93 | PDPK1 (0.55) | PDPK1ROCK1AURKBAURKAKMT2A | |
| SCHEMBL1320153 | 0.90 | PDPK1 (0.47) | PDPK1ROCK1AURKBAURKAKMT2A | |
| SCHEMBL12119430 | 0.86 | PDPK1 (0.48) | PDPK1ROCK1AURKBAURKAKMT2A | |
| SCHEMBL1316893 | 0.84 | PDPK1 (0.72) | PDPK1ROCK1AURKBAURKA | |
| SCHEMBL1317811 | 0.83 | PDPK1 (0.52) | PDPK1ROCK1AURKBAURKAKMT2A | |
| SCHEMBL13354773 | 0.81 | PDPK1 (0.62) | PDPK1ROCK1AURKBAURKAKMT2A | |
| SCHEMBL13354854 | 0.81 | PDPK1 (0.71) | PDPK1ROCK1AURKBAURKAKMT2A | |
| SCHEMBL13354858 | 0.81 | PDPK1 (0.59) | PDPK1ROCK1AURKBAURKAKMT2A | |
| SCHEMBL12122781 | 0.80 | PDPK1 (0.60) | PDPK1ROCK1AURKBAURKAKMT2A | |
| SCHEMBL13354765 | 0.80 | PDPK1 (0.60) | PDPK1ROCK1AURKBAURKAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |