Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 8/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.60 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12119846 | 0.90 | AURKA (0.56) | AURKAPDPK1AURKBRETHRH3 | |
| SCHEMBL12119858 | 0.87 | AURKA (0.53) | AURKAPDPK1AURKBSCN2APDE10A | |
| SCHEMBL13354783 | 0.87 | AURKA (0.72) | AURKAPDPK1AURKBSCN2AHRH3 | |
| SCHEMBL12119859 | 0.84 | PDPK1 (0.65) | AURKAPDPK1AURKB | |
| SCHEMBL12119847 | 0.84 | PDPK1 (0.83) | AURKAPDPK1AURKB | |
| SCHEMBL12119856 | 0.83 | PDPK1 (0.74) | AURKAPDPK1AURKB | |
| SCHEMBL12119848 | 0.80 | AURKA (0.53) | AURKAPDPK1AURKBPDE10APIK3R1 | |
| SCHEMBL16966473 | 0.77 | AURKA (0.52) | AURKAPDPK1AURKBHRH3HRH4 | |
| SCHEMBL1318114 | 0.77 | AURKA (0.68) | AURKAPDPK1AURKBHRH3HRH4 | |
| SCHEMBL16966437 | 0.74 | AURKA (0.48) | AURKAPDPK1AURKBSCN2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |