Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 20/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 17/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.61 |
| ▸ | AURKA | O14965 | 11/20 | 0.61 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13354769 | 0.94 | PDPK1 (0.68) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1319090 | 0.93 | PDPK1 (0.71) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1321262 | 0.86 | PDPK1 (0.70) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1318522 | 0.86 | PDPK1 (0.70) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1318704 | 0.86 | PDPK1 (0.79) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1320516 | 0.85 | PDPK1 (0.68) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL12122710 | 0.82 | PDPK1 (0.49) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL13354779 | 0.81 | PDPK1 (0.69) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1318420 | 0.81 | PDPK1 (0.69) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1318996 | 0.81 | PDPK1 (0.80) | PDPK1AURKBROCK1AURKATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |