Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.72 |
| ▸ | FLT3 | P36888 | 20/20 | 0.72 |
| ▸ | CDK2 | P24941 | 16/20 | 0.72 |
| ▸ | TYK2 | P29597 | 10/20 | 0.72 |
| ▸ | JAK1 | P23458 | 8/20 | 0.72 |
| ▸ | JAK3 | P52333 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823870 | 0.83 | JAK2 (1.00) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL824050 | 0.74 | JAK2 (0.82) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL823965 | 0.70 | JAK2 (0.78) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL824053 | 0.69 | JAK2 (0.75) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL824015 | 0.69 | JAK2 (1.00) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL824047 | 0.68 | JAK2 (0.77) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL824052 | 0.68 | JAK2 (0.77) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL824031 | 0.68 | FLT3 (0.71) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL824123 | 0.68 | FLT3 (0.72) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL9912312 | 0.67 | JAK2 (0.69) | JAK2FLT3CDK2TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951730-B1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | S BIO PTE LTD (SG) | 2010-05-26 | — | — | EP | disclosed |