Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.62 |
| ▸ | JAK2 | O60674 | 11/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13355571 | 0.89 | PLK1 (0.49) | PLK1JAK2HDAC1HDAC6JAK3 | |
| SCHEMBL4786448 | 0.83 | PLK1 (0.71) | PLK1JAK2HDAC1HDAC6SYK | |
| SCHEMBL4736493 | 0.80 | PLK1 (0.83) | PLK1JAK2HDAC1HDAC6SYK | |
| SCHEMBL4733852 | 0.78 | PLK1 (0.84) | PLK1JAK2SYKJAK3NPC1 | |
| SCHEMBL4735155 | 0.77 | PLK1 (1.00) | PLK1JAK2HDAC1HDAC6SYK | |
| SCHEMBL15827662 | 0.77 | PIK3CG (0.48) | PLK1JAK2HDAC1HDAC6SYK | |
| SCHEMBL4376512 | 0.76 | PLK1 (0.72) | PLK1JAK2SYKJAK3NPC1 | |
| SCHEMBL14172776 | 0.76 | PLK1 (0.72) | PLK1JAK2HDAC1HDAC6SYK | |
| SCHEMBL4736544 | 0.75 | PLK1 (0.76) | PLK1JAK2SYKJAK3ABL1 | |
| SCHEMBL4735847 | 0.75 | PLK1 (0.71) | PLK1JAK2HDAC1HDAC6SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951730-B1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | S BIO PTE LTD (SG) | 2010-05-26 | — | — | EP | disclosed |