Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.57 |
| ▸ | TYK2 | P29597 | 9/20 | 0.56 |
| ▸ | JAK1 | P23458 | 8/20 | 0.56 |
| ▸ | JAK3 | P52333 | 8/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 1/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL402670 | 0.83 | JAK2 (0.58) | JAK2TYK2JAK1JAK3CYP1A2 | |
| SCHEMBL13355591 | 0.83 | JAK2 (0.47) | JAK2TYK2JAK1JAK3NTRK1 | |
| SCHEMBL402594 | 0.79 | JAK2 (0.71) | JAK2TYK2JAK1JAK3CYP1A2 | |
| SCHEMBL405027 | 0.75 | JAK2 (0.67) | JAK2TYK2JAK1JAK3CYP1A2 | |
| SCHEMBL403855 | 0.74 | JAK2 (0.66) | JAK2TYK2JAK1JAK3CYP1A2 | |
| SCHEMBL22640727 | 0.74 | EPHB3 (0.62) | JAK2TYK2JAK1JAK3CYP1A2 | |
| SCHEMBL406315 | 0.74 | JAK2 (0.83) | JAK2TYK2JAK1JAK3CYP1A2 | |
| SCHEMBL22640713 | 0.74 | JAK2 (0.74) | JAK2TYK2JAK1JAK3CYP1A2 | |
| SCHEMBL402995 | 0.74 | JAK2 (0.82) | JAK2TYK2JAK1JAK3CYP3A4 | |
| SCHEMBL403687 | 0.74 | JAK2 (0.78) | JAK2TYK2JAK1JAK3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010051549-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-05-06 | — | — | WO | disclosed |