Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | DTYMK | P23919 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 3/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3127337 | 0.82 | PDK4 (0.46) | PDK4GRM5CHRM2CHRM4CHRM1 | |
| SCHEMBL13355687 | 0.78 | AVPR1A (0.39) | PDK4CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL507146 | 0.72 | NR1H2 (0.61) | PDK4CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL20660009 | 0.69 | MAPK1 (0.41) | PDK4CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL20660010 | 0.69 | MAPK1 (0.41) | PDK4CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL30500962 | 0.69 | MAPK1 (0.41) | PDK4CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL17282284 | 0.69 | USP2 (0.47) | GRM5CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL3714994 | 0.69 | USP2 (0.47) | GRM5CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL2454099 | 0.69 | USP2 (0.47) | GRM5CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL31628983 | 0.69 | PDK4 (0.59) | PDK4GRM5CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056633-A2 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-20 | — | — | WO | disclosed |