Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 9/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | FES | P07332 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.42 |
| ▸ | FER | P16591 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8445630 | 0.84 | NTRK1 (0.48) | AXLALKCDK8TNIKJAK2 | |
| SCHEMBL4402102 | 0.84 | JAK2 (0.63) | AXLALKCDK8TNIKJAK2 | |
| SCHEMBL8445000 | 0.84 | ALK (0.46) | AXLALKCDK8TNIKJAK2 | |
| SCHEMBL8488878 | 0.84 | AXL (0.46) | AXLALKCDK8TNIKJAK2 | |
| SCHEMBL8443762 | 0.83 | AXL (0.52) | AXLALKCDK8TNIKGSK3B | |
| SCHEMBL13505050 | 0.81 | AXL (0.44) | AXLALKCDK8TNIKJAK2 | |
| SCHEMBL3353882 | 0.81 | AXL (0.50) | AXLALKCDK8TNIKGSK3B | |
| SCHEMBL8280138 | 0.81 | ITK (0.46) | AXLALKGSK3BJAK2PLK4 | |
| SCHEMBL29952518 | 0.80 | AXL (0.70) | AXLCDK8TNIKGSK3BJAK2 | |
| SCHEMBL8320062 | 0.80 | AXL (0.54) | AXLALKCDK8TNIKCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720871-B1 | 3,5-DISUBSTITUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2010-05-19 | — | — | EP | disclosed |