Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 4/20 | 0.41 |
| ▸ | SCARB1 | Q8WTV0 | 2/20 | 0.40 |
| ▸ | FBP1 | P09467 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359157 | 0.90 | MAPK14 (0.53) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL1302196 | 0.87 | MAPK14 (0.57) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL1302956 | 0.87 | MAPK14 (0.58) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13798002 | 0.87 | MAPK14 (0.58) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13798005 | 0.86 | MAPK14 (0.59) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13359214 | 0.86 | MAPK14 (0.59) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL1303140 | 0.86 | MAPK14 (0.58) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL1302347 | 0.84 | MAPK14 (0.56) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL1302236 | 0.84 | MAPK14 (0.58) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13810719 | 0.84 | MAPK14 (0.56) | MAPK14LYNMAPK9BRAFSCARB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |