Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.50 |
| ▸ | RXRA | P19793 | 2/20 | 0.50 |
| ▸ | RXRB | P28702 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367676 | 0.81 | APP (0.55) | APPNR4A2RXRARXRBLMNA | |
| SCHEMBL22275947 | 0.80 | APP (0.82) | APPNR4A2RXRARXRBLMNA | |
| SCHEMBL780050 | 0.79 | APP (0.53) | APPNR4A2RXRARXRBLMNA | |
| SCHEMBL5024279 | 0.77 | IDO1 (0.63) | KMT2A | |
| SCHEMBL1691492 | 0.77 | APP (0.52) | APPNR4A2RXRARXRBLMNA | |
| SCHEMBL2516121 | 0.77 | IDO1 (0.63) | APP | |
| SCHEMBL14263412 | 0.77 | APP (0.51) | APPNR4A2RXRARXRBLMNA | |
| SCHEMBL5509258 | 0.77 | APP (0.70) | APPNR4A2RXRARXRBLMNA | |
| SCHEMBL13439793 | 0.77 | APP (0.70) | APPNR4A2RXRARXRBLMNA | |
| SCHEMBL8251933 | 0.76 | APP (0.50) | APPNR4A2RXRARXRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7714130-B2 | Processes for preparing gonadotropin releasing hormone receptor antagonists | WYETH (US) | 2010-05-11 | — | — | US | disclosed |