Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554639 | 0.81 | MAPK14 (0.54) | CCNA2CDK2CCNT1CDK9CDK5 | |
| SCHEMBL13382569 | 0.80 | CCNT1 (0.49) | CCNA2CDK2CCNT1CDK9CDK5 | |
| SCHEMBL13382571 | 0.80 | KDM4E (0.47) | CCNA2CDK2CCNT1CDK9CDK5 | |
| SCHEMBL13359303 | 0.79 | JAK3 (0.35) | JAK3IDO1L3MBTL1POLBDYRK1A | |
| SCHEMBL5094782 | 0.77 | CCNT1 (0.42) | CCNA2CDK2CCNT1CDK9CDK5 | |
| SCHEMBL13199646 | 0.77 | CCNT1 (0.46) | CCNA2CDK2CCNT1CDK9CDK5 | |
| SCHEMBL989130 | 0.76 | CCNT1 (0.45) | CCNA2CDK2CCNT1CDK9CDK5 | |
| SCHEMBL3912533 | 0.75 | CCNA2 (0.44) | CCNA2CDK2CCNT1CDK9CDK5 | |
| SCHEMBL3917686 | 0.75 | CCNT1 (0.44) | CCNA2CDK2CCNT1CDK9CDK5 | |
| SCHEMBL14480569 | 0.74 | APP (0.53) | JAK3IDO1DYRK1AADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521749-B1 | PHENYL-(4-(3-PHENYL-1H-PYRAZOL-4-YL)-PYRIMIDIN-2-Yl)-AMINE DERIVATIVES | NOVARTIS AG (CH) | 2010-05-19 | — | — | EP | disclosed |