Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 17/20 | 0.72 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1336444 | 0.89 | CACNA1B (0.61) | CACNA1B | |
| SCHEMBL1336123 | 0.88 | CACNA1B (0.56) | CACNA1BSCN9ACHRM4 | |
| SCHEMBL1334915 | 0.86 | CACNA1B (0.71) | CACNA1B | |
| SCHEMBL1337325 | 0.85 | CACNA1B (0.66) | CACNA1B | |
| SCHEMBL1337198 | 0.84 | CACNA1B (0.65) | CACNA1B | |
| SCHEMBL1337234 | 0.84 | CACNA1B (1.00) | CACNA1BCHRM4 | |
| SCHEMBL1336994 | 0.84 | CACNA1B (1.00) | CACNA1BCHRM4 | |
| SCHEMBL1335029 | 0.84 | CACNA1B (0.77) | CACNA1BCHRM4 | |
| SCHEMBL1335119 | 0.84 | CACNA1B (0.77) | CACNA1B | |
| SCHEMBL1335041 | 0.84 | CACNA1B (0.77) | CACNA1BCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281870-A1 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | claimed |
| US-20110281870-A1 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281870-A1 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | CACNA1C, ORAI1, CACNA1S | CACNA1B 5/4885SCN9A 241/4885CHRM4 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.