Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 14/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 14/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 14/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 14/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 14/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 14/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3186389 | 1.00 | CA12 (0.50) | CA12CA1CA2CA3CA4 | |
| SCHEMBL3199398 | 0.81 | PSEN1 (0.59) | CA12CA1CA2CA3CA4 | |
| SCHEMBL3185840 | 0.79 | PSEN1 (0.45) | CA12CA1CA2CA3CA4 | |
| SCHEMBL3179699 | 0.78 | PSEN1 (0.45) | CA12CA1CA2CA3CA4 | |
| SCHEMBL2337848 | 0.77 | PSEN1 (0.50) | CA12CA1CA2CA3CA4 | |
| SCHEMBL2337853 | 0.77 | PSEN1 (0.50) | CA12CA1CA2CA3CA4 | |
| SCHEMBL3188980 | 0.76 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3198148 | 0.75 | PSEN1 (0.45) | CA12CA1CA2CA9PSEN1 | |
| SCHEMBL3178164 | 0.74 | CNR1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3177085 | 0.74 | PSEN1 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120725-A1 | Substituted Phenylsulfonamide Inhibitors of Beta Amyloid Production | WYETH LLC (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120725-A1 | Substituted Phenylsulfonamide Inhibitors of Beta Amyloid Production | APP, BACE1, PSEN1 | CA12 4351/4885CA1 1302/4885CA2 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.