Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | INSR | P06213 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.35 |
| ▸ | LGMN | Q99538 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13362089 | 0.83 | MAPT (0.46) | KCNH2INSRALKCYP3A4CYP2C9 | |
| SCHEMBL3313268 | 0.82 | IGF1R (0.47) | KCNH2ALKCYP3A4GAKIGF1R | |
| SCHEMBL13362048 | 0.82 | CCR1 (0.36) | KCNH2CYP2C19GAKMEN1KMT2A | |
| SCHEMBL3345793 | 0.81 | GAK (0.38) | KCNH2CYP3A4GAKIGF1RHTR4 | |
| SCHEMBL3314196 | 0.81 | GAK (0.39) | ALKCYP3A4GAKBRD4 | |
| SCHEMBL13362105 | 0.80 | SMN1; SMN2 (0.42) | KCNH2IGF1RMEN1KMT2AHTR4 | |
| SCHEMBL13362043 | 0.80 | ALK (0.38) | KCNH2ALKCYP3A4GAKIGF1R | |
| SCHEMBL13362030 | 0.80 | IGF1R (0.42) | KCNH2CYP3A4GAKIGF1RHTR4 | |
| SCHEMBL13362088 | 0.80 | GAK (0.37) | KCNH2GAKIGF1RKMT2AHTR4 | |
| SCHEMBL13362038 | 0.80 | ALK (0.40) | ALKGAKKMT2AHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |