Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 4/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1557547 | 0.94 | PRKDC (0.48) | PRKDCFGFR1FLT1PIK3CAPIK3CD | |
| SCHEMBL2396779 | 0.73 | LRRK2 (0.47) | PRKDCPIK3CAPIK3CDPIK3CBMAPK1 | |
| SCHEMBL1558837 | 0.72 | LRRK2 (0.43) | PRKDCFGFR1FLT1PIK3CAPIK3CD | |
| SCHEMBL2395048 | 0.67 | HRH4 (0.55) | MAPK1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL26912263 | 0.66 | LRRK2 (0.57) | FGFR1FLT1ITKMAPK1MAPK10 | |
| SCHEMBL1558730 | 0.65 | GAA (0.47) | PRKDCKDM4EMEN1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL31543151 | 0.64 | MAPK1 (0.49) | MAPK1 | |
| SCHEMBL8871230 | 0.64 | PIK3CD (0.80) | PIK3CAPIK3CDPIK3CB | |
| SCHEMBL18108512 | 0.64 | PIK3CA (0.63) | PRKDCPIK3CAPIK3CDPIK3CBPDE3B | |
| SCHEMBL23999520 | 0.63 | MAPKAPK2 (0.54) | PRKDCPIK3CAPIK3CDPIK3CBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155527-A9 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
| WO-2009155527-A2 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. (US) | 2009-12-23 | — | — | WO | disclosed |