Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491583 | 0.87 | PDE10A (0.71) | PDE10ANPC1RAB9AGAAKDR | |
| SCHEMBL2462411 | 0.86 | PDE10A (0.68) | PDE10ANPC1RAB9AGAAKDR | |
| SCHEMBL2488399 | 0.86 | PDE10A (0.68) | PDE10ANPC1RAB9AGAAKDR | |
| SCHEMBL3319583 | 0.86 | PDE10A (0.68) | PDE10ANPC1RAB9AGAAKDR | |
| SCHEMBL3320311 | 0.84 | PDE10A (0.64) | PDE10ANPC1RAB9AGAAKDR | |
| SCHEMBL2493015 | 0.84 | PDE10A (0.64) | PDE10ANPC1RAB9AKDR | |
| SCHEMBL2486654 | 0.84 | PDE10A (0.64) | PDE10ANPC1RAB9A | |
| SCHEMBL2493989 | 0.83 | PDE10A (0.63) | PDE10ANPC1RAB9A | |
| SCHEMBL2489700 | 0.81 | PDE10A (1.00) | PDE10ANPC1RAB9APDE4APDE4B | |
| SCHEMBL2490606 | 0.80 | PDE10A (1.00) | PDE10ANPC1RAB9APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057126-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2010-05-20 | — | — | WO | disclosed |