Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.52 |
| ▸ | EGLN3 | Q9H6Z9 | 13/20 | 0.52 |
| ▸ | EGLN2 | Q96KS0 | 10/20 | 0.52 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.52 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3424100 | 0.86 | EGLN1 (0.56) | EGLN1EGLN3EGLN2OGFOD1HIF1AN | |
| SCHEMBL3420490 | 0.82 | EGLN1 (0.65) | EGLN1EGLN3EGLN2OGFOD1HIF1AN | |
| SCHEMBL3420471 | 0.80 | EGLN1 (0.65) | EGLN1EGLN3EGLN2OGFOD1HIF1AN | |
| SCHEMBL3421184 | 0.79 | EGLN1 (0.61) | EGLN1EGLN3EGLN2OGFOD1HIF1AN | |
| SCHEMBL3422072 | 0.79 | EGLN1 (0.61) | EGLN1EGLN3EGLN2OGFOD1HIF1AN | |
| SCHEMBL3419612 | 0.79 | EGLN1 (0.69) | EGLN1EGLN3EGLN2OGFOD1HIF1AN | |
| SCHEMBL3423767 | 0.79 | EGLN3 (0.60) | EGLN1EGLN3EGLN2OGFOD1HIF1AN | |
| SCHEMBL3423763 | 0.78 | EGLN1 (0.61) | EGLN1EGLN3EGLN2OGFOD1HIF1AN | |
| SCHEMBL3421029 | 0.78 | EGLN1 (0.61) | EGLN1EGLN3EGLN2OGFOD1HIF1AN | |
| SCHEMBL3419280 | 0.77 | EGLN1 (0.64) | EGLN1EGLN3EGLN2OGFOD1HIF1AN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324208-B2 | Prolyl hydroxylase inhibitors | GLAXOSMITHKLINE LLC (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100113444-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113444-A1 | PROLYL HYDROXYLASE INHIBITORS | HIF1AN, EGLN3, EGLN2 | EGLN1 6/4885EGLN3 2/4885EGLN2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.