Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 10/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 5/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3419496 | 0.87 | EGLN3 (0.55) | EGLN3EGLN1EGLN2HIF1ACYSLTR2 | |
| SCHEMBL13367268 | 0.85 | EGLN3 (0.48) | EGLN3EGLN1EGLN2HIF1ACYSLTR2 | |
| SCHEMBL13367259 | 0.83 | EGLN3 (0.48) | EGLN3EGLN1EGLN2HDAC1HDAC8 | |
| SCHEMBL13367266 | 0.80 | EGLN3 (0.48) | EGLN3EGLN1EGLN2CYSLTR2 | |
| SCHEMBL13367220 | 0.77 | EGLN3 (0.54) | EGLN3EGLN1EGLN2CYSLTR2 | |
| SCHEMBL13367267 | 0.77 | EGLN1 (0.60) | EGLN3EGLN1EGLN2CYSLTR2 | |
| SCHEMBL3418304 | 0.74 | EGLN3 (0.58) | EGLN3EGLN1EGLN2 | |
| SCHEMBL3422070 | 0.71 | EGLN3 (0.62) | EGLN3EGLN1EGLN2 | |
| SCHEMBL3421421 | 0.71 | EGLN3 (0.65) | EGLN3EGLN1EGLN2HIF1ACYSLTR2 | |
| SCHEMBL18134558 | 0.71 | EGLN3 (0.49) | EGLN3EGLN1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324208-B2 | Prolyl hydroxylase inhibitors | GLAXOSMITHKLINE LLC (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100113444-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113444-A1 | PROLYL HYDROXYLASE INHIBITORS | HIF1AN, EGLN3, EGLN2 | EGLN3 2/4885EGLN1 6/4885EGLN2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.