Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13372951 | 1.00 | PDE10A (0.54) | PDE10AGRIN1GRIN2B | |
| SCHEMBL13372939 | 1.00 | PDE10A (0.54) | PDE10AGRIN1GRIN2B | |
| SCHEMBL13372940 | 1.00 | PDE10A (0.54) | PDE10AGRIN1GRIN2B | |
| SCHEMBL11989588 | 0.83 | PDE10A (0.57) | PDE10A | |
| SCHEMBL11989097 | 0.83 | PDE10A (0.57) | PDE10A | |
| SCHEMBL11989622 | 0.83 | PDE10A (0.57) | PDE10A | |
| SCHEMBL11989098 | 0.83 | PDE10A (0.57) | PDE10A | |
| SCHEMBL1304174 | 0.82 | PDE10A (0.79) | PDE10A | |
| SCHEMBL1304028 | 0.82 | PDE10A (0.79) | PDE10A | |
| SCHEMBL1303966 | 0.82 | PDE10A (0.79) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364308-B1 | PYRAZINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC (US) | 2012-10-24 | — | — | EP | disclosed |