Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 9/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13373028 | 0.99 | ACKR3 (0.52) | ACKR3CHRM4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL13373034 | 0.89 | ACKR3 (0.50) | ACKR3CHRM4KDM4EALDH1A1LMNA | |
| SCHEMBL13373002 | 0.89 | ACKR3 (0.56) | ACKR3CHRM4ALDH1A1MAPTKCNH2 | |
| SCHEMBL13373127 | 0.89 | ACKR3 (0.53) | ACKR3CHRM4HTR2AHTR2CHTR7 | |
| SCHEMBL13373003 | 0.88 | ACKR3 (0.55) | ACKR3CHRM4ALDH1A1HTR2AHTR2C | |
| SCHEMBL13372982 | 0.88 | CHRM4 (0.51) | ACKR3CHRM4KDM4EHTR2AHTR2C | |
| SCHEMBL13372986 | 0.87 | ACKR3 (0.51) | ACKR3CHRM4HTR2AHTR2CHTR7 | |
| SCHEMBL13373004 | 0.87 | ACKR3 (0.51) | ACKR3CHRM4HTR2AHTR2CHTR7 | |
| SCHEMBL13373118 | 0.87 | ACKR3 (0.51) | ACKR3CHRM4HTR2AHTR2CHTR7 | |
| SCHEMBL13372991 | 0.86 | ACKR3 (0.50) | ACKR3CHRM4HTR2AHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288373-B2 | Modulators of CXCR7 | CHEMOCENTRYX, INC. (US) | 2012-10-16 | — | — | US | disclosed |