Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16498153 | 1.00 | KCNH2 (0.43) | KCNH2CACNA1BALDH1A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL2425444 | 0.91 | KCNH2 (0.47) | KCNH2CACNA1BKMT2ADRD2DRD4 | |
| SCHEMBL1334977 | 0.90 | CACNA1B (0.51) | KCNH2CACNA1BALDH1A1SIGMAR1DRD2 | |
| SCHEMBL16497805 | 0.90 | CACNA1B (0.51) | KCNH2CACNA1BALDH1A1SIGMAR1DRD2 | |
| SCHEMBL16497791 | 0.90 | CACNA1B (0.51) | KCNH2CACNA1BALDH1A1SIGMAR1DRD2 | |
| SCHEMBL65557 | 0.87 | NPC1 (0.44) | KCNH2CACNA1BALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL1335062 | 0.81 | KMT2A (0.48) | CACNA1BSMN1; SMN2KMT2A | |
| SCHEMBL66703 | 0.79 | NPC1 (0.45) | KCNH2CACNA1BALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL65982 | 0.78 | CACNA1B (0.44) | KCNH2CACNA1BSIGMAR1 | |
| SCHEMBL66167 | 0.78 | CACNA1B (0.47) | KCNH2CACNA1BALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281870-A1 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281870-A1 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | CACNA1C, ORAI1, CACNA1S | KCNH2 24/4885CACNA1B 5/4885ALDH1A1 556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.