Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 14/20 | 0.57 |
| ▸ | EP300 | Q09472 | 13/20 | 0.57 |
| ▸ | BRD4 | O60885 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RBP4 | P02753 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5953472 | 0.88 | HCAR2 (0.56) | CREBBPEP300BRD4MAPK1HCAR2 | |
| SCHEMBL14970405 | 0.81 | CREBBP (0.59) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL30128141 | 0.81 | CYP2C19 (0.60) | HCAR2KMT2ATSHR | |
| SCHEMBL4792110 | 0.81 | ADORA1 (0.46) | CREBBPEP300BRD4MAPK1HCAR2 | |
| SCHEMBL13373961 | 0.81 | CREBBP (0.53) | CREBBPEP300BRD4MAPK1RBP4 | |
| SCHEMBL17785625 | 0.80 | MAPK1 (0.56) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL31496063 | 0.80 | MAPK1 (0.56) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL21255655 | 0.80 | MAPK1 (0.56) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL17795280 | 0.80 | MAPK1 (0.60) | CREBBPEP300BRD4MAPK1 | |
| SCHEMBL17229697 | 0.79 | MAPK1 (0.55) | CREBBPEP300BRD4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |