Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5374018 | 0.87 | PRKCI (0.44) | PRKCIACHEBACE1GAAMAPT | |
| SCHEMBL26601544 | 0.83 | TSHR (0.44) | PRKCIACHEGAAMAPTTSHR | |
| SCHEMBL8594722 | 0.83 | PRKCI (0.37) | PRKCIACHEBACE1GAAMAPT | |
| SCHEMBL13375301 | 0.83 | PRKCI (0.46) | PRKCIACHEBACE1GAAMAPT | |
| SCHEMBL13886946 | 0.83 | PRKCI (0.41) | PRKCIACHEBACE1GAAMAPT | |
| SCHEMBL29738343 | 0.83 | PRKCI (0.47) | PRKCIACHEBACE1GAAMAPT | |
| SCHEMBL395438 | 0.83 | PRKCI (0.47) | PRKCIACHEBACE1GAAMAPT | |
| SCHEMBL20679733 | 0.82 | PRKCI (0.36) | PRKCIACHEGAAMAPTTSHR | |
| SCHEMBL23864412 | 0.80 | TYR (0.44) | PRKCIACHEGAAMAPTTSHR | |
| SCHEMBL31265082 | 0.79 | HTT (0.44) | PRKCIACHEBACE1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |