Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 14/20 | 0.68 |
| ▸ | ICOSLG | O75144 | 9/20 | 0.68 |
| ▸ | ICOS | Q9Y6W8 | 9/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.60 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13377082 | 0.83 | CHUK (0.72) | CHUKICOSLGICOSMEN1KMT2A | |
| SCHEMBL14253055 | 0.83 | CHUK (0.73) | CHUKICOSLGICOSMEN1KMT2A | |
| SCHEMBL13377041 | 0.81 | CHUK (1.00) | CHUKICOSLGICOSMEN1KMT2A | |
| SCHEMBL14253036 | 0.81 | CHUK (0.77) | CHUKICOSLGICOSMEN1KMT2A | |
| SCHEMBL14253074 | 0.80 | CHUK (0.65) | CHUKICOSLGICOSMEN1KMT2A | |
| SCHEMBL14253069 | 0.79 | CHUK (0.72) | CHUKICOSLGICOSMEN1KMT2A | |
| SCHEMBL14253007 | 0.79 | CHUK (0.76) | CHUKICOSLGICOSMEN1KMT2A | |
| SCHEMBL14253043 | 0.79 | CHUK (0.72) | CHUKICOSLGICOSMEN1KMT2A | |
| SCHEMBL13377038 | 0.78 | CHUK (1.00) | CHUKICOSLGICOSMEN1KMT2A | |
| SCHEMBL13452572 | 0.78 | CHUK (1.00) | CHUKICOSLGICOSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268477-B1 | SUBSTITUTED BETA-CARBOLINES WITH IKB-KINASE INHIBITING ACTIVITY | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-04-21 | — | — | EP | disclosed |
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |