Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 15/20 | 0.89 |
| ▸ | ICOSLG | O75144 | 10/20 | 0.89 |
| ▸ | ICOS | Q9Y6W8 | 10/20 | 0.89 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | IKBKB | O14920 | 1/20 | 0.80 |
| ▸ | PIM1 | P11309 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.80 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.80 |
| ▸ | CCKBR | P32239 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13377038 | 0.94 | CHUK (1.00) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL14253078 | 0.92 | CHUK (0.83) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL14253005 | 0.92 | CHUK (0.83) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL14253037 | 0.92 | CHUK (1.00) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL14253053 | 0.90 | CHUK (0.84) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL14253041 | 0.89 | CHUK (1.00) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL14253052 | 0.89 | CHUK (0.78) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL2768947 | 0.89 | CHUK (0.78) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL2768231 | 0.89 | CHUK (0.78) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL29359984 | 0.89 | CHUK (1.00) | CHUKICOSLGICOSMEN1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268477-B1 | SUBSTITUTED BETA-CARBOLINES WITH IKB-KINASE INHIBITING ACTIVITY | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-04-21 | — | — | EP | disclosed |
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |