Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 20/20 | 0.79 |
| ▸ | PPARA | Q07869 | 9/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.63 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.63 |
| ▸ | DRD2 | P14416 | 1/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.63 |
| ▸ | TACR2 | P21452 | 1/20 | 0.63 |
| ▸ | DRD1 | P21728 | 1/20 | 0.63 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.63 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5119415 | 1.00 | PPARG (0.79) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL2896771 | 1.00 | PPARG (0.79) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL5119422 | 0.94 | PPARG (0.70) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL5111563 | 0.94 | PPARG (0.70) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL13384217 | 0.92 | PPARG (0.74) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL370978 | 0.92 | PPARG (0.74) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL2903844 | 0.92 | PPARG (0.74) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL5126400 | 0.90 | PPARG (0.76) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL2898596 | 0.89 | PPARG (0.64) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL14266922 | 0.89 | PPARG (0.64) | PPARGPPARACYP2C9EGFRCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537078-B1 | INDOLES HAVING ANTI-DIABETIC ACTIVITY | MERCK SHARP & DOHME (US) | 2010-04-14 | — | — | EP | disclosed |
| US-7345085-B2 | Indoles having anti-diabetic activity | MERCK & CO., INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-7186746-B2 | Indoles having anti-diabetic activity | MERCK & CO., INC. (US) | 2007-03-06 | — | — | US | disclosed |