Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 18/20 | 0.48 |
| ▸ | HTR7 | P34969 | 16/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366817 | 0.89 | HTR2B (0.50) | HTR2BHTR7DRD2ADRA1DHTR2A | |
| SCHEMBL12366701 | 0.89 | HTR2B (0.50) | HTR2BHTR7DRD2ADRA1DHTR2A | |
| SCHEMBL12389306 | 0.86 | HTR2B (0.47) | HTR2BHTR7DRD2ADRA1DHTR2A | |
| SCHEMBL12366702 | 0.85 | HTR2B (0.46) | HTR2BHTR7DRD2ADRA1DHTR2A | |
| SCHEMBL12366819 | 0.85 | HTR2B (0.46) | HTR2BHTR7DRD2ADRA1DHTR2A | |
| SCHEMBL12366719 | 0.83 | HTR2B (0.53) | HTR2BHTR7DRD2ADRA1DHTR2A | |
| SCHEMBL12366666 | 0.82 | HTR2B (0.52) | HTR2BHTR7DRD2ADRA1DHTR2A | |
| SCHEMBL12366654 | 0.82 | HTR2B (0.52) | HTR2BHTR7DRD2ADRA1DHTR2A | |
| SCHEMBL12366660 | 0.82 | HTR2B (0.52) | HTR2BHTR7DRD2ADRA1DHTR2A | |
| SCHEMBL13384418 | 0.82 | PDK2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177505-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-04-21 | — | — | EP | disclosed |