Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.58 |
| ▸ | CCND1 | P24385 | 9/20 | 0.58 |
| ▸ | CDK2 | P24941 | 5/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.57 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.55 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.54 |
| ▸ | CCND3 | P30281 | 4/20 | 0.52 |
| ▸ | CCND2 | P30279 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13385837 | 0.88 | NUAK1 (0.65) | CDK4CCND1CDK2CCNA2NUAK1 | |
| SCHEMBL13385848 | 0.85 | CDK4 (0.68) | CDK4CCND1CDK2CCNA2MAPK9 | |
| SCHEMBL13385810 | 0.84 | CDK4 (0.64) | CDK4CCND1CDK2CCNA2NUAK1 | |
| SCHEMBL13554032 | 0.83 | CDK4 (0.70) | CDK4CCND1CDK2CCNA2MAPK9 | |
| SCHEMBL13385770 | 0.82 | PLK2 (0.73) | CDK4CCND1CDK2CCNA2PLK2 | |
| SCHEMBL13385796 | 0.82 | CDK2 (0.57) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL3971264 | 0.78 | MAPK9 (0.62) | CDK4CCND1CDK2CCNA2MAPK9 | |
| SCHEMBL13385911 | 0.77 | CDK4 (0.66) | CDK4CCND1CDK2CCNA2MAPK9 | |
| SCHEMBL13385755 | 0.77 | KMT2A (0.45) | CDK4CCND1CDK2CCNA2PLK2 | |
| SCHEMBL13385804 | 0.77 | CDK4 (0.65) | CDK4CCND1CDK2CCNA2NUAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889696-B2 | Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof | Temple University—Of the Commonwealth System of Higher Education (US) | 2014-11-18 | — | — | US | claimed |
| US-20120269831-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-10-25 | — | — | US | claimed |
| US-8889696-B2 | Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof | Temple University—Of the Commonwealth System of Higher Education (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889696-B2 | Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof | Temple University—Of the Commonwealth System of Higher Education (US) | 2014-11-18 | — | — | US | disclosed |
| US-20120269831-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120269831-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | MKI67, CCNA1, FOLR1 | CDK4 86/4885CCND1 90/4885CDK2 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.