Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.57 |
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 4/20 | 0.40 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13388170 | 0.77 | GRM5 (0.65) | FFAR1GRM5CHRM2SIGMAR1SLC16A3 | |
| SCHEMBL10020217 | 0.74 | GRM4 (0.64) | FFAR1GRM5KDM4EALDH1A1 | |
| SCHEMBL27950423 | 0.72 | FFAR1 (0.55) | FFAR1GRM5CHRM2SIGMAR1SLC16A3 | |
| SCHEMBL13388104 | 0.71 | GRM5 (0.65) | GRM5P4HTM | |
| SCHEMBL13388350 | 0.71 | GRM5 (0.65) | GRM5CHRM2SIGMAR1SLC16A3P4HA1 | |
| SCHEMBL13730442 | 0.71 | P4HTM (0.53) | FFAR1GRM5CHRM2SIGMAR1P4HA1 | |
| SCHEMBL10020221 | 0.71 | FFAR1 (0.56) | FFAR1GRM5KDM4EALDH1A1 | |
| SCHEMBL708798 | 0.71 | FFAR1 (0.56) | FFAR1GRM5 | |
| SCHEMBL16011593 | 0.71 | P4HTM (0.50) | GRM5CHRM2SIGMAR1SLC16A3P4HA1 | |
| SCHEMBL319105 | 0.69 | KDM4E (0.53) | FFAR1P4HTMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699547-B1 | 5-(PHENYL/PYRIDINYL-ETHINYL)-2-PYRIDINE/2-PYRIMIDINE-CARBORXAMIDES AS MGLUR5 MODULATORS | HOFFMANN LA ROCHE (CH) | 2015-03-04 | — | — | EP | disclosed |
| US-8772300-B2 | Phenyl or pyridinyl-ethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | disclosed |
| EP-2699547-A1 | 5-(PHENYL/PYRIDINYL-ETHINYL)-2-PYRIDINE/ 2-PYRIMIDINE-CARBORXAMIDES AS MGLUR5 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143340-A1 | 5-(PHENYL/PYRIDINYL-ETHINYL)-2-PYRIDINE/ 2-PYRIMIDINE-CARBORXAMIDES AS MGLUR5 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-26 | — | — | WO | disclosed |
| US-20120270852-A1 | PHENYL OR PYRIDINYL-ETHYNYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270852-A1 | PHENYL OR PYRIDINYL-ETHYNYL DERIVATIVES | GRM5, GRM1, GRM3 | FFAR1 80/4885GRM5 1/4885CHRM2 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.