Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.85 |
| ▸ | INSR | P06213 | 1/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.66 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.66 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13393645 | 0.91 | IGF1R (0.80) | IGF1RINSRMAPK8MAPK10ALK | |
| SCHEMBL12429376 | 0.87 | IGF1R (0.86) | IGF1RINSRMAPK8MAPK10ALK | |
| SCHEMBL12429488 | 0.86 | IGF1R (1.00) | IGF1RINSRMAPK8MAPK10ALK | |
| SCHEMBL15219359 | 0.85 | IGF1R (0.84) | IGF1RINSRMAPK8MAPK10ALK | |
| SCHEMBL13393644 | 0.84 | IGF1R (0.85) | IGF1RINSRMAPK8MAPK10ALK | |
| SCHEMBL12429560 | 0.82 | IGF1R (0.90) | IGF1RINSRMAPK8MAPK10ALK | |
| SCHEMBL12429321 | 0.81 | IGF1R (1.00) | IGF1RINSRMAPK8MAPK10ALK | |
| SCHEMBL12429561 | 0.81 | IGF1R (1.00) | IGF1RINSRMAPK8MAPK10ALK | |
| Gsk-1220512A SCHEMBL12429476 | 0.81 | IGF1R (1.00) | IGF1RINSRMAPK8MAPK10ALK | |
| SCHEMBL11918997 | 0.81 | IGF1R (0.82) | IGF1RINSRMAPK8MAPK10ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045451-A1 | PYRROLOPYRIMIDINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-22 | — | — | WO | disclosed |