Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 5/20 | 0.51 |
| ▸ | CDK8 | P49336 | 5/20 | 0.51 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 7/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | PASK | Q96RG2 | 1/20 | 0.42 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22311425 | 0.76 | CACNA1H (0.58) | CCNCCDK8CACNA1HHTR2APASK | |
| SCHEMBL13548299 | 0.76 | CTNNB1 (0.47) | CCNCCDK8CACNA1HVNN1PDE1C | |
| SCHEMBL17316406 | 0.75 | KDM4E (0.53) | CCNCCDK8CACNA1HVNN1KDM2B | |
| SCHEMBL14800197 | 0.74 | NOTUM (0.52) | CCNCCDK8CACNA1HHTR2APASK | |
| SCHEMBL30903411 | 0.74 | NOTUM (0.52) | CCNCCDK8CACNA1HHTR2APASK | |
| SCHEMBL30006720 | 0.74 | PDE1C (0.48) | CCNCCDK8CACNA1HVNN1PDE1C | |
| SCHEMBL29698372 | 0.74 | CCNC (0.65) | CCNCCDK8ACSS2HTR2APASK | |
| SCHEMBL6172461 | 0.73 | HDAC1 (0.57) | CCNCCDK8HSD17B1HSD17B2 | |
| SCHEMBL14387746 | 0.73 | HDAC1 (0.53) | HSD17B1HSD17B2 | |
| SCHEMBL20652664 | 0.72 | NPY5R (0.48) | CCNCCDK8ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044187-A1 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | SCHERING CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |