Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | LIPE | Q05469 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13122674 | 0.84 | MAPT (0.45) | MAPTHDAC4HDAC6LIPEGPR119 | |
| SCHEMBL13107110 | 0.84 | MAPT (0.45) | MAPTHDAC4HDAC6LIPEGPR119 | |
| SCHEMBL13122483 | 0.84 | MAPT (0.45) | MAPTHDAC4HDAC6LIPEGPR119 | |
| SCHEMBL13107109 | 0.84 | MAPT (0.45) | MAPTHDAC4HDAC6LIPEGPR119 | |
| SCHEMBL13106854 | 0.83 | MAPT (0.44) | MAPTHDAC4HDAC6LIPEGPR119 | |
| SCHEMBL27158505 | 0.81 | USP30 (0.44) | HDAC4HDAC6GPR119USP30MEN1 | |
| SCHEMBL29202347 | 0.81 | USP30 (0.44) | HDAC4HDAC6GPR119USP30MEN1 | |
| SCHEMBL29280846 | 0.80 | CHEK2 (0.54) | MAPTHDAC4HDAC6LIPEGPR119 | |
| SCHEMBL30842586 | 0.80 | CHEK2 (0.54) | MAPTHDAC4HDAC6LIPEGPR119 | |
| SCHEMBL29280843 | 0.80 | CHEK2 (0.54) | MAPTHDAC4HDAC6LIPEGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7692019-B2 | Methods for the stereoselective synthesis of substituted piperidines | SEPRACOR INC. (US) | 2010-04-06 | — | — | US | disclosed |