Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13403450 | 0.88 | SMN1; SMN2 (0.55) | KMT2ACNR1KDM4E | |
| SCHEMBL10921358 | 0.74 | KMT2A (1.00) | MEN1KMT2APOLBCNR1HTR3A | |
| SCHEMBL10553825 | 0.74 | KMT2A (1.00) | MEN1KMT2APOLBCNR1HTR3A | |
| SCHEMBL13403447 | 0.74 | MEN1 (0.51) | MEN1KMT2APOLBKDM4E | |
| Bromide SCHEMBL10553700 | 0.73 | KMT2A (0.97) | MEN1KMT2APOLBCNR1HTR3A | |
| SCHEMBL14574173 | 0.73 | CNR1 (0.74) | MEN1KMT2APOLBCNR1PRMT3 | |
| Bromide SCHEMBL10556088 | 0.73 | KMT2A (0.97) | MEN1KMT2APOLBCNR1HTR3A | |
| SCHEMBL12974664 | 0.73 | EPHX1 (0.56) | — | |
| SCHEMBL10923255 | 0.73 | KMT2A (0.97) | MEN1KMT2APOLBCNR1HTR3A | |
| SCHEMBL2527623 | 0.72 | MEN1 (0.74) | MEN1KMT2APOLBCNR1PRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696217-B2 | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2010-04-13 | — | — | US | disclosed |
| US-7696217-B2 | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2010-04-13 | — | — | US | disclosed |