Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.69 |
| ▸ | KIT | P10721 | 3/20 | 0.69 |
| ▸ | BRAF | P15056 | 3/20 | 0.69 |
| ▸ | RET | P07949 | 2/20 | 0.69 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.69 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.69 |
| ▸ | CIT | O14578 | 1/20 | 0.69 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.69 |
| ▸ | STK10 | O94804 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | EGFR | P00533 | 1/20 | 0.69 |
| ▸ | RAF1 | P04049 | 1/20 | 0.69 |
| ▸ | LCK | P06239 | 1/20 | 0.69 |
| ▸ | FYN | P06241 | 1/20 | 0.69 |
| ▸ | CSF1R | P07333 | 1/20 | 0.69 |
| ▸ | YES1 | P07947 | 1/20 | 0.69 |
| ▸ | LYN | P07948 | 1/20 | 0.69 |
| ▸ | HCK | P08631 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3144781 | 0.92 | KDR (0.81) | KDRKITBRAFRETMAP3K20 | |
| SCHEMBL3155086 | 0.90 | KDR (0.69) | KDRKITBRAFRETMAP3K20 | |
| SCHEMBL3150119 | 0.90 | KDR (0.85) | KDRKITBRAFRETMAP3K20 | |
| SCHEMBL3150757 | 0.88 | KDR (0.64) | KDRKITBRAFRETMAP3K20 | |
| SCHEMBL3151947 | 0.88 | KDR (0.67) | KDRKITBRAFRETMAP3K20 | |
| SCHEMBL13417728 | 0.88 | KDR (0.66) | KDRKITBRAFRETMAP3K20 | |
| SCHEMBL3155362 | 0.86 | KDR (0.64) | KDRKITBRAFRETMAP3K20 | |
| SCHEMBL3159874 | 0.86 | KDR (0.61) | KDRKITBRAFRETMAP3K20 | |
| SCHEMBL3154986 | 0.84 | KDR (0.63) | KDRKITBRAFRETMAP3K20 | |
| SCHEMBL3145270 | 0.84 | KDR (0.61) | KDRKITBRAFRETMAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687643-B2 | Process for preparing 3,3-dimethylindolines | AMGEN INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687643-B2 | Process for preparing 3,3-dimethylindolines | AMGEN INC. (US) | 2010-03-30 | — | — | US | disclosed |