Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2397797 | 0.92 | MAPK14 (0.45) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL12259600 | 0.92 | MAPK14 (0.45) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL13419076 | 0.89 | MAPK14 (0.44) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL13419186 | 0.88 | MAPK14 (0.45) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2394695 | 0.84 | MAPK14 (0.45) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2394870 | 0.84 | MAPK14 (0.45) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2396356 | 0.83 | MAPK14 (0.46) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL12259599 | 0.83 | MAPK14 (0.46) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL12259601 | 0.82 | MAPK14 (0.45) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2390581 | 0.82 | MAPK14 (0.45) | MAPK14CYP2C9MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039079-A1 | ISOQUINOLINONE DERIVATIVES | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |