Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 8/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 8/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13421317 | 0.97 | TYK2 (0.46) | TYK2PRKCQCCNE1CDK2FLT3 | |
| SCHEMBL3318540 | 0.88 | TYK2 (0.44) | TYK2PRKCQCCNE1CDK2FLT3 | |
| SCHEMBL3312224 | 0.85 | PRKCQ (0.44) | TYK2PRKCQSTAT3PDE4D | |
| SCHEMBL13421744 | 0.84 | PRKCQ (0.41) | TYK2PRKCQCCNE1CDK2FLT3 | |
| SCHEMBL13421747 | 0.83 | PRKCQ (0.41) | TYK2PRKCQPDE4D | |
| SCHEMBL13421314 | 0.81 | TYK2 (0.55) | TYK2CCNE1CDK2FLT3STAT3 | |
| SCHEMBL13421529 | 0.80 | PRKCQ (0.39) | TYK2PRKCQPDE4D | |
| SCHEMBL13421853 | 0.79 | TYK2 (0.51) | TYK2CCNE1CDK2FLT3STAT3 | |
| SCHEMBL13422051 | 0.75 | PRKCQ (0.40) | TYK2PRKCQCCNE1CDK2FLT3 | |
| SCHEMBL3313894 | 0.73 | PRKCQ (0.39) | TYK2PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042699-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |