Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13422207 | 0.91 | NPSR1 (0.50) | NPSR1HCRTR1HCRTR2KMT2ASMN1; SMN2 | |
| SCHEMBL13422214 | 0.87 | NPSR1 (0.53) | NPSR1HCRTR1HCRTR2KMT2ASMN1; SMN2 | |
| SCHEMBL13422136 | 0.86 | KMT2A (0.60) | NPSR1HCRTR1HCRTR2KMT2ASMN1; SMN2 | |
| SCHEMBL13422209 | 0.86 | NPC1 (0.53) | NPSR1HCRTR1HCRTR2KMT2ASMN1; SMN2 | |
| SCHEMBL13422215 | 0.83 | NPSR1 (0.54) | NPSR1HCRTR1HCRTR2KMT2ASMN1; SMN2 | |
| SCHEMBL13422160 | 0.81 | KMT2A (0.49) | NPSR1HCRTR1HCRTR2KMT2ASMN1; SMN2 | |
| SCHEMBL14432816 | 0.80 | KDM4E (0.50) | NPSR1HCRTR1HCRTR2KMT2ASMN1; SMN2 | |
| SCHEMBL13422380 | 0.80 | NPSR1 (0.42) | NPSR1HCRTR1HCRTR2KMT2ASMN1; SMN2 | |
| SCHEMBL13422216 | 0.77 | KDM4E (0.51) | NPSR1HCRTR1HCRTR2KMT2ASMN1; SMN2 | |
| SCHEMBL13422376 | 0.76 | NPSR1 (0.46) | NPSR1HCRTR1HCRTR2KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| EP-1636218-B1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2009-03-25 | — | — | EP | disclosed |