SCHEMBL13423936 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	EGFR	P00533	20/20	0.76

▸	ERBB2	P04626	20/20	0.76

▸	ERBB3	P21860	14/20	0.76

▸	ERBB4	Q15303	14/20	0.76

▸	BMPR1B	O00238	1/20	0.76

▸	EPHB6	O15197	1/20	0.76

▸	LCK	P06239	1/20	0.76

▸	LYN	P07948	1/20	0.76

▸	MET	P08581	1/20	0.76

▸	CSK	P41240	1/20	0.76

▸	MAP2K1	Q02750	1/20	0.76

▸	MAP2K5	Q13163	1/20	0.76

▸	AURKB	Q96GD4	1/20	0.76

▸	NLK	Q9UBE8	1/20	0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2747601	0.90	EGFR (0.90)	EGFRERBB2ERBB3ERBB4BMPR1B
SCHEMBL13429724	0.88	EGFR (0.82)	EGFRERBB2ERBB3ERBB4BMPR1B
SCHEMBL2750968	0.88	EGFR (0.89)	EGFRERBB2ERBB3ERBB4BMPR1B
SCHEMBL2750283	0.87	EGFR (0.77)	EGFRERBB2ERBB3ERBB4BMPR1B
SCHEMBL2748841	0.86	EGFR (0.75)	EGFRERBB2ERBB3ERBB4BMPR1B
Tak-285 SCHEMBL29355721	0.86	EGFR (1.00)	EGFRERBB2ERBB3ERBB4BMPR1B
Tak-285 SCHEMBL982278	0.86	EGFR (1.00)	EGFRERBB2ERBB3ERBB4BMPR1B
SCHEMBL2747525	0.86	EGFR (1.00)	EGFRERBB2ERBB3ERBB4BMPR1B
SCHEMBL2748925	0.86	EGFR (0.86)	EGFRERBB2ERBB3ERBB4BMPR1B
SCHEMBL20365459	0.85	EGFR (0.91)	EGFRERBB2ERBB3ERBB4BMPR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2010036910-A1	HEART PROTECTION BY ADMINISTERING AN AMP-ACTIVATED PROTEIN KINASE ACTIVATOR	OHTA YOSHIKAZU (JP)	2010-04-01	—	—	WO	disclosed