Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13425457 | 0.86 | MAP2K4 (0.40) | NR1H2HASPINGPR119MAP2K4PSEN1 | |
| SCHEMBL13794562 | 0.83 | DYRK1A (0.44) | DYRK1AMAP2K4BRD4MCL1 | |
| SCHEMBL177544 | 0.81 | KMT2A (0.49) | — | |
| SCHEMBL177320 | 0.81 | MAOB (0.43) | SLC22A12 | |
| SCHEMBL426350 | 0.79 | NR1H2 (0.42) | SLC22A12NR1H2MAP2K4BRD4 | |
| SCHEMBL7605898 | 0.79 | ELANE (0.44) | SLC22A12NR1H2GPR119MAP2K4BRD4 | |
| SCHEMBL176840 | 0.78 | ESR2 (0.41) | SLC22A12NR1H2MAP2K4 | |
| SCHEMBL28266630 | 0.78 | LSS (0.37) | NR1H2LSSGPR119DYRK1AMAP2K4 | |
| SCHEMBL8212259 | 0.77 | MAP2K4 (0.40) | SLC22A12NR1H2MAP2K4BRD4 | |
| SCHEMBL11232 | 0.77 | PDGFRA (0.47) | SLC22A12MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010041569-A1 | INDAZOLE COMPOUND | 旭化成ファーマ株式会社 (JP) | 2010-04-15 | — | — | WO | disclosed |