Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 17/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13399907 | 0.76 | AURKA (0.51) | AURKAAURKBCCNE1CDK2CDK5 | |
| SCHEMBL13399921 | 0.76 | AURKA (0.54) | AURKAAURKBNTRK2DDR2PLK4 | |
| SCHEMBL13399918 | 0.75 | AURKA (0.48) | AURKAAURKBCCNE1CDK2CDK5 | |
| SCHEMBL13399916 | 0.75 | AURKA (0.48) | AURKAAURKBCCNE1CDK2CDK5 | |
| SCHEMBL13399968 | 0.74 | AURKA (0.70) | AURKAAURKBCSF1RRAF1 | |
| SCHEMBL13399912 | 0.74 | AURKA (0.52) | AURKAAURKB | |
| SCHEMBL13399913 | 0.74 | AURKA (0.48) | AURKAAURKBCCNE1CDK2CDK5 | |
| SCHEMBL13399890 | 0.69 | AURKA (0.57) | AURKAAURKBCCNE1CDK2CDK5 | |
| SCHEMBL13399895 | 0.69 | AURKA (0.73) | AURKAAURKBNTRK2MAPTNTRK3 | |
| SCHEMBL13399900 | 0.69 | AURKA (0.61) | AURKAAURKBNTRK2DDR2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100081675-A1 | FUSED MULTICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081675-A1 | FUSED MULTICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS | AURKC, AURKA, AURKB | AURKA 2/4885AURKB 3/4885CCNE1 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.