SCHEMBL13428549

SCHEMBL13428549

N#Cc1ccc2c(c1)CN(C(=O)c1cccs1)[C@H](Cc1ccccc1)CN2Cc1cnc[nH]1

nearest known ligand 0.77

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ FNTA P49354 20/20 0.77
▸ FNTB P49356 20/20 0.77
▸ HRAS P01112 1/20 0.70
▸ KRAS P01116 1/20 0.70
▸ PGGT1B P53609 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bms-214662 SCHEMBL94663 0.82 FNTA (1.00) FNTAFNTBHRASKRASPGGT1B
Bms-214662 SCHEMBL16499911 0.82 FNTA (1.00) FNTAFNTBHRASKRASPGGT1B
SCHEMBL22050804 0.81 FNTA (0.69) FNTAFNTBHRASKRASPGGT1B
SCHEMBL13524156 0.77 FNTA (0.76) FNTAFNTBHRASKRASPGGT1B
SCHEMBL22050803 0.77 FNTA (0.86) FNTAFNTBHRASKRASPGGT1B
SCHEMBL12308297 0.75 FNTA (0.81) FNTAFNTBHRASKRASPGGT1B
SCHEMBL3500650 0.74 FNTA (0.60) FNTAFNTBHRASKRASPGGT1B
SCHEMBL3500647 0.74 FNTA (0.60) FNTAFNTBHRASKRASPGGT1B
SCHEMBL3499563 0.73 FNTA (0.59) FNTAFNTBHRASKRASPGGT1B
SCHEMBL3499558 0.73 FNTA (0.59) FNTAFNTBHRASKRASPGGT1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1689782-B1 ANTI-IGFR1 ANTIBODY THERAPEUTIC COMBINATIONS SCHERING CORP (US) 2010-04-21 — — EP disclosed
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