Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3155023 | 1.00 | MAPT (0.35) | MAPTCYP3A4MAPK1ALDH1A1CYP2D6 | |
| SCHEMBL13428637 | 1.00 | MAPT (0.35) | MAPTCYP3A4MAPK1ALDH1A1CYP2D6 | |
| SCHEMBL4247917 | 0.93 | HTR2A (0.37) | MAPTCYP3A4MAPK1ALDH1A1CYP2D6 | |
| SCHEMBL15158554 | 0.93 | HTR2A (0.37) | MAPTCYP3A4MAPK1ALDH1A1CYP2D6 | |
| SCHEMBL15158556 | 0.93 | HTR2A (0.37) | MAPTCYP3A4MAPK1ALDH1A1CYP2D6 | |
| SCHEMBL7431595 | 0.88 | CYP3A4 (0.43) | MAPTCYP3A4MAPK1ALDH1A1CYP2D6 | |
| SCHEMBL333286 | 0.88 | CYP3A4 (0.43) | MAPTCYP3A4MAPK1ALDH1A1CYP2D6 | |
| SCHEMBL29693809 | 0.88 | CYP3A4 (0.43) | MAPTCYP3A4MAPK1ALDH1A1CYP2D6 | |
| SCHEMBL13428611 | 0.88 | CYP3A4 (0.43) | MAPTCYP3A4MAPK1ALDH1A1CYP2D6 | |
| SCHEMBL7543257 | 0.82 | HTR2C (0.46) | ALDH1A1HTR2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778930-B2 | Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine | LES LABORATORIES SERVIER (FR) | 2014-07-15 | — | — | US | disclosed |
| US-20130211070-A1 | NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE | LES LABORATOIRES SERVIER (FR) | 2013-08-15 | — | — | US | disclosed |
| US-20100056778-A1 | Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl) nitrile and application in the synthesis of ivabradine | LES LABORATOIRES SERVIER (FR) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130211070-A1 | NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE | HCN4, NISCH, SCN5A | MAPT 4647/4885CYP3A4 8/4885MAPK1 1569/4885 |
| US-20100056778-A1 | Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl) nitrile and application in the synthesis of ivabradine | HCN4, NISCH, SCN5A | MAPT 4569/4885CYP3A4 9/4885MAPK1 1644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.